Abstract
Background and Aims: Bold Hypertriglyceridemia has emerged as an important coronary artery disease (CAD) risk factor. Rare loss of function (LOF) variants in apolipoprotein CIII have been reported to reduce triglycerides (TG) and decrease the risk of CAD in American Indians and Europeans. However, there is a paucity of data on whether these variants are cardioprotective in other European and non-European populations. Also, whether genetically increased TG due to ApoCIII is causally associated with increased CAD risk is still unclear and inconsistent.
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