Abstract
BackgroundThe goal of the study is to investigate the association between the APOA5 polymorphisms and haplotypes with Arterial Hypertension (AHT) in Moroccan patients.MethodsThe study was performed in 283 subjects, 149 patients with AHT and 134 controls. All subjects were genotyped for the APOA5 -1131 T > C (rs662799), 56C > G (rs3135506) and c.553G > T (rs2075291) polymorphisms.ResultsThere was a strong association between -1131 T > C and 56C > G polymorphisms with AHT. The -1131 T > C and 56C > G polymorphisms were significantly associated with increased systolic blood pressure (SBP) and triglycerides (TG) levels. There were 4 haplotypes with a frequency higher than 5%, constructed from APOA5 polymorphisms, with the following order: -1131 T > C, 56C > G and c.553G > T. Haplotype H1 (TCG) was associated with decreased risk of AHT, whereas the haplotypes H2 (CCG) and H4 (CGG) were significantly associated with an increased risk of AHT. Carriers of H1 haplotype had a lower SBP and DBP and TG. In contrast, significant elevated SBP, DBP and TG were found in H4 haplotypes carriers.ConclusionsOur data demonstrate for the first time that several common SNPs in the APOA5 gene and their haplotypes are closely associated with modifications of blood pressure and serum lipid parameters in the AHT patient.
Highlights
The goal of the study is to investigate the association between the Apolipoprotein A5 (APOA5) polymorphisms and haplotypes with Arterial Hypertension (AHT) in Moroccan patients
We investigated the association of the APOA5 polymorphisms and haplotypes with AHT in Moroccan patients
Age, triglyceridemia (TG), LDL, total cholesterol (TC), Glycemia (Gly), CT/HDL ratio, Sbp and Dbp were significantly different between AHT patients and controls
Summary
The goal of the study is to investigate the association between the APOA5 polymorphisms and haplotypes with Arterial Hypertension (AHT) in Moroccan patients. The American Heart Association reported that the hypertension and dyslipidemia are one of the main risk factor for development of CAD [3,4]. Apolipoprotein A5 (APOA5) gene, related to the metabolism of triglycerides in several different ethnic groups [5]. It locates on chromosome 11q23, and forms a cluster with APOA4, APOC3 and APOA1 genes. Numerous studies in different ethnic populations have shown significant associations between two minor APOA5 haplotypes, APOA5*2 and APOA5*3, and elevated plasma triglyceride levels [5,8]. It is estimated that 53% of Hispanics, 35% of African-Americans, and 24% of Caucasians carry at least one of these two haplotypes [6], suggesting that these haplotypes are common risk factors for atherosclerosis
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