Abstract
Metastasis is one of the major obstacles limiting the success treatment of cancer. Annexin A1 (ANXA1) is a key member of the subfamily and belongs to the multi-gene family of annexins, which is known to play an important role in cancer progression and metastasis. Although there were controversies surrounding the relationship between ANXA1 and metastasis, the role of ANXA1 in cancer metastasis has been increasingly recognized. Numerous ANXA1-related signaling pathways are involved in cancer metastasis. Recently through microarray experiments demonstrate that ANXA1 could regulate microRNAs (miRNAs) in cancer, such as miRNA-196a (miR-196a), microRNA-26 (miR-26) and microRNA-562 (miR-562), which promoted cell proliferation and angiogenesis. ANXA1 could regulate miRNAs to directly target NF-κB, estrogen receptor (ER) and angiogenesis gene transcripts. Thus, ANXA1 mediates cancer metastasis may via regulation of miRNA signaling. This review describes the mechanism by which ANXA1 contributes to cancer metastasis and summarizes new advances in research in ANXA1associated cancer metastasis.
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