Association of antimüllerian hormone levels with menstrual-cycle type and dysmenorrhea in young asymptomatic women

Abstract

To examine the association between antimüllerian hormone (AMH) levels and menstrual-cycle and lifestyle characteristics among young Japanese women. Cross-sectional study. University. Female students aged 20-22 years (n=65) who had never used oral contraceptives. Participants completed a questionnaire on reproductive and lifestyle characteristics, and kept a menstrual-cycle diary for 5 consecutive months. Serum AMH was measured once during the study period. Serum AMH concentration. Compared with women with very mild menstrual pain, serum AMH concentration was 49.6% (95% CI 6.5%-72.8%) lower among women with severe menstrual pain. Higher AMH concentration was associated with irregular menstrual cycles. Even after adjusting for menstrual-cycle regularity and its interaction, more-severe menstrual pain was associated with significantly lower AMH concentration. Circulating AMH concentration was significantly lower among young Japanese women who had more-severe menstrual pain. Underlying physiological mechanisms need to be addressed in future studies.