Abstract
Background: Different immune mechanisms of myocardial damage involved in the pathophysiology of Chagas disease coexist with high titers of autoantibodies induced by T. cruzi . There are few studies in the literature about the adaptive role of anti-β1 and anti-M2 antibodies in chronic Chagas cardiomyopathy (CCC). Objectives: To evaluate the association between anti-β1 and anti-M2 antibodies with heart rate variability (HRV) parameters on 24h Holter monitoring and the rate-pressure product (RPP) on cardiopulmonary exercise testing (CPET). Methods: Anti-β1 and [...]
Highlights
The elucidation of its pathogenesis was marked by pivotal studies that evaluated cross-reactivity between the ribosomal P protein of Trypanosoma cruzi and human ribosomal proteins, as well as by advances in the knowledge of the structure of β-adrenergic receptors, used as antigens to screen for specific anti-β-adrenergic antibodies in chronic Chagas cardiomyopathy (CCC).[4,5]
The present study investigated the association of high titers of anti-β1 and anti-M2 antibodies in CCC with autonomic dysfunction as assessed by heart rate variability (HRV) and the behavior of the ratepressure product (RPP) during cardiopulmonary exercise testing (CPET)
This was a cross-sectional study of 64 patients with CCC recruited from the outpatient cardiomyopathy clinic at the Instituto Nacional de Cardiologia (INC)
Summary
There are few studies in the literature about the adaptive role of anti-β1 and anti-M2 antibodies in chronic Chagas cardiomyopathy (CCC). Objectives: To evaluate the association between anti-β1 and anti-M2 antibodies with heart rate variability (HRV) parameters on 24h Holter monitoring and the rate-pressure product (RPP) on cardiopulmonary exercise testing (CPET). Methods: Anti-β1 and anti-M2 antibody titers were measured by enzyme-linked immunosorbent assay (ELISA) in 64 patients affected by CCC. Regarding CPET variables, anti-β1 titers were directly associated with RPP (rs=0.371, p=0.005, n=56). RPP was an independent explanatory variable for anti-β1 titers, with a low coefficient of determination (R2=0.147). Conclusion: The findings of this study suggest that, in patients with CCC, anti-β1 and anti-M2 antibodies may affect HRV parameters. RPP was directly associated with higher anti-β1 titers.
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