Association of ANGPTL8 gene polymorphism with the occurrence of coronary artery disease in Iraqi patients

Abstract

OBJECTIVE: It has been shown that ANGPTL8 controls the metabolism of fatty acids and triglycerides (TG). Reduced adipogenesis, which was defined by decreased TG, was linked to decreased ANGPTL8. The aim of the present study was to evaluate the association of ANGPTL8 gene polymorphism with the occurrence of coronary artery disease in Iraqi population. RESEARCH DESIGN AND METHODS: two hundred coronary artery disease patients with >70 blockage coronary artery as well as to 200 apparently individuals who were diagnosed as negative findings by coronary angiography (Control group) were investigated for several biochemical parameters as well as genotyping for rs892066 and rs2278426 of ANGPTL8 gene SNPs by ARM-PCR technique. RESULTS: The examinations of rs892066 approved significant varaition after the adjustment for age and sex under the codominant model in heterozygous genotype, and under the dominant model the GG+CG genotype in patients group was be higher than of control group. The assessment of the minor allele frequency (G) approved the association of rs892066 in the occurrence of CAD. Along with the most recent outcomes, Multinominal logistic regression analysis was used to analyze the genotype and allele frequencies of the rs2278426 ANGPTL8 gene polymorphism in CAD and control individuals under the codominant, dominant, recessive, and overdominant models. The examinations failed to explore significant varaition after the adjustment for age, sex and BMI and smoking status. The assessment of the minor allel frequency (T) indicated that no association between presence minor allel frequency (T) in CAD patients and the control group. CONCLUSIONS: SNP rs892066 may play unique role in the occurrence of CAD while rs2278426 of ANGPTL8 genes are not associated with CAD in Iraqi patients.