Association of Ang-2, vWF, and EVLWI with risk of mortality in sepsis patients with concomitant ARDS: A retrospective study

Abstract

This study aimed to determine the potential effects of angiopoietin-2 (Ang-2), von Willebrand factor (vWF), and extravascular lung water index (EVLWI) on the risk of mortality in sepsis patients with concomitant acute respiratory distress syndrome (ARDS). This retrospective study recruited 41 sepsis patients with concomitant ARDS from January 2015 to June 2018. Data of Ang-2 and vWF levels, EVLWI, and sequential organ failure assessment scores were collected at 0, 24, and 48h after admission to the hospital. The length of intensive care unit stay (P=0.041) and Acute Physiology and Chronic Health Evaluation-2 (APACHE II) score (P=0.003) were associated with the risk of mortality. Furthermore, increased Ang-2 levels and EVLWI at 24h and 48h were associated with an increased risk of mortality. Moreover, the APACHE II score at hospital admission significantly predicted the risk of mortality (area under the curve [AUC], 0.834; 95% confidence interval [CI], 0.665-0.983). Finally, the models containing a combination of Ang-2 level and EVLWI at 24h (AUC, 0.908; 95% CI, 0.774-0.996) and Ang-2 level and EVLWI at 48h (AUC, 0.981; 95% CI, 0.817-1.000) had high diagnostic values for predicting risk of mortality. The study findings indicate that Ang-2 levels and EVLWI at 24h and 48h after admission are significantly associated with the risk of mortality.