Abstract
BackgroundAlpha B-crystallin (CRYAB) is a protein that functions as “molecular chaperone” in preserving intracellular architecture and cell membrane. Also, CRYAB is highly antiapoptotic. Abnormal CRYAB expression is a prognostic biomarker for oral cancer, while its genomic variations and the association with carcinogenesis have never been studied.Methodology/FindingTherefore, we hypothesized that CRYAB single nucleotide polymorphisms may be associated with oral cancer risk. In this hospital-based study, the association of CRYAB A-1215G (rs2228387), C-802G (rs14133) and intron2 (rs2070894) polymorphisms with oral cancer in a Taiwan population was investigated. In total, 496 oral cancer patients and 992 age- and gender-matched healthy controls were genotyped and analyzed. A significantly different frequency distribution was found in CRYAB C-802G genotypes, but not in A-1215G and intron2 genotypes, between the oral cancer and control groups. The CRYAB C-802G G allele conferred an increased risk of oral cancer (P = 1.49×10−5). Patients carrying CG/GG at CRYAB C-802G were of lower 5-year survival and higher recurrence rate than those of CC (P<0.05).Conclusion/SignificanceOur results provide the first evidence that the G allele of CRYAB C-802G is correlated with oral cancer risk and this polymorphism may be a useful marker for oral cancer recurrence and survival prediction for clinical reference.
Highlights
Oral cancer, which is a leading cause of death and disfigurement around the world [1,2,3,4], has ranked on the 4th cancer in Taiwanese male population [5]
Conclusion/Significance: Our results provide the first evidence that the G allele of CRYAB C-802G is correlated with oral cancer risk and this polymorphism may be a useful marker for oral cancer recurrence and survival prediction for clinical reference
Genotype distribution of various genetic polymorphisms of CRYAB C-802G is significantly different between oral cancer and control groups (P,0.05), while those for A-1215G or intron 2 were not significant (P.0.05) (Table 2)
Summary
Oral cancer, which is a leading cause of death and disfigurement around the world [1,2,3,4], has ranked on the 4th cancer in Taiwanese male population [5]. There is an urgent need to develop routine preoperative markers to spare patients with poor prognosis after surgery or other treatment and on the other hand, identify patients at risk of early recurrence and justify prophylactic neck dissection and adjuvant concurrent chemoradiotherapy as well as those who could benefit from various treatments regardless of their tumor size or staging. Those who are identified at higher risk of oral cancer recurrence and/or metastasis should be detected earlier and followed up more frequently to enjoy longer life with the development of useful markers for prognosis prediction. Abnormal CRYAB expression is a prognostic biomarker for oral cancer, while its genomic variations and the association with carcinogenesis have never been studied
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