Association of alcohol drinking with initial acute myocardial infarction of male patients in Inner Mongolia area

Abstract

Objective To investigate the relationship of alcohol consumption with risk factors,biochemical indexes,severity of coronary stenosis,cardiac function and recurrent cardiovascular events after a fellow up of 6 months in male patients with initial Acute Myocardial Infarction(AMI).Methods One hundred and eighty-six male patients were selected as our subjects who were initially diagnosed as AMI.Thepatients were divided into non alcohol group,moderate drinking group and heavy drinking group.They were conducted 6 month follow up.The clinical data and the occurrence of recurrent cardiovascular events were recorded.Results Average age of non-drinker group and moderate drinking group were (60.30 ± 11.87) year and (62.52 ± ± 10.05) year,older than that of heavy drinking group ((54.77 ± 11.37) year; P ＜ 0.05)).Percentage of smoking in heavy drinking group was 97.10％,higher than that in non-drinker group (78.38％) (P ＜ 0.05).Meanwhile,the levels of serum aspartate aminotransferase,alanine aminotransferase,urea in heavy drinking group were 58.24 (13.48) mmol/L,56.34 (12.98) mmol/L,(326.77 ± 67.72) μmol/L respectively,higher than that in non-alcohol group(45.36(11.32) mmol/L,36.25(9.62) mmol/L,(293.68 ±52.29) μmol/L;P ＜ 0.05).However,the left ventricular ejection factor,fractional shortening,E/A were (49.51 ± 9.62) ％,(28.09 ± 4.89)％,(0.83 ± 0.31) in heavy drinking group,lower than that in non alcohol group((54.35 ± ± 8.61) ％,(30.86 ± 5.08) ％,1.01 ± 0.43 ; P ＜ 0.05).High-density lipoproteincholesterol levels were significantly lower while triglyceride levels were much higher in heavy drinking group than moderate drinking group ((0.94±0.23 mmol/Lvs.(1.12 ±0.39) mmol/L;2.18(0.65) mmol/L vs.1.46(0.46) mmol/L;P ＜0.05).Serum levels of high-density lipoproteincholesterol in moderate drinking group was (1.12 ± 0.39) mmol/L,significantly higher than that in non-alcohol group ((0.95 ±0.30) mmol/L,P ＜0.05).The highest percentage of recurrent cardiovascular events in the heavy drinking groups was 25.72％ (18/70),higher than other two groups (13.51％ (10/74),9.5％ (4/42) ; P ＜ 0.05).Logistic regression analysis indicated that smoking (OR =3.648,95 ％ CI:1.025-12.968,P =0.046),diabetes (OR =7.068,95 ％ CI:1.049-15.284,P =0.013) were both independent predictors of the recurrent cardiovascular events.Conclusion Patients with heavy drinking show younger ages with initial AMI,higher incidences of dyslipidemia,and poorer cardiac systolic/diastolic function.Recurrent cardiovascular events in a 6 month follow up were positively correlated with smoking and diabetes.Moderate drinking might be helpful to improve the disorders of lipid metabolism in AMI patients. Key words: Alcohol drinking; Acute myocardial infarction; Risk factors; Male