ASSOCIATION OF ALBUMINURIAAND URIC ACID IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Abstract

Introduction: There are two possibilities of increase serum uric acid level it could be increase production or decrease excretion higher serum uric acid level in diabetic nephropathy is mostly due to abnormality in uric acid excretion or hyperuricemia may result from increased net tubular reabsorption. On the other hand, higher levels of serum insulin may decrease uric acid clearance by the kidneys. Today there is great interest in the potential that uric acid may represent a remediable risk factor for CKD. So we studied the relation between hyperuricemia and albuminuria in type 2 diabetes mellitus patients in asansol district hospital west Bengal.Aims: The aim of this study is to evaluate the association between serum uric acid & urinary Albumin to Creatinine Ratio (ACR) among patients with type 2 diabetes mellitus. Materials And Methods: This study was hospital based observational and prospective study to nd out relationship between serum uric acid level & albuminuria in type 2 Diabetes Mellitus patients. 83 patients aged between 40 to 80 years was selected from Medicine OPD and indoor wards, Department of General Medicine, KPC Hospital, West Bengal from 1august 2020 to 1august 2021. Type 2 Diabetics Melitus (T2DM) patients and Age: between 40 to 80 years were included in this study. Result: 41(49.4%) patients had Normoalbuminuria, 26(31.3%) patients had Microalbuminuria and 16(19.3%) patients had Macroalbuminuria.37(44.6%) patients had Hyperuricemia and 46(55.4%) patients had Normouricemia.25(30.1%) patients had ALT. Association of hypertensive / normotensive vs. Albuminuria was not statistically signicant (p=0.3579).Association of hyperuricemia / normouricemia vs. Albuminuria was statistically signicant (p<0.0001)..Poor control of HBA1C was signicantly associated with albumin excretion in urine (p<0.0001).Distribution of mean GFR vs. albuminuria was statistically signicant (p<0.0001). Distribution of mean urinary ACR vs. albuminuria was statistically signicant (p<0.0001). Distribution of mean serum uric acid vs. albuminuria was statistically signicant (p<0.0001). Conclusion : Hypertension, raised HbA1C levels, high blood sugar levels and raised serum creatinine levels are the major risk factors. Hence early detection of high risk patients and the early initiation of renal and cardiovascular protective agents helps in reducing morbidity and mortality due to type 2 diabetes mellites. There was negative correlation between serum uric acid with GFR and HDL, which were statistically signicant.