Association of adiponectin, free fatty acids, and insulin resistance with metabolic syndrome and its components in Uygur Xinjiang province

Abstract

Objective To investigate the association of adiponectin (APN),free fatty acids (FFA),and insulin resistance(IR) with metabolic syndrome (MS) and its components.Methods In the baseline survey,the subjects were divided into MS group and the control group based on the criteria of 2005 International Diabetes Federation,and randomly selected 218 and 201 cases for the study.APN was measured by ELISA,FFA by colorimetry,fasting insulin by radioimmunoassay.Results FFA and IR were significantly higher in subjects with MS than that without MS,while APN was lower(P＜0.01).FFA and IR rose gradually along with the increased number of MS components(P＜0.01),while APN descended.The incidence and risk of MS and its abnormal components were significantly higher in the Q4 group with higher level of FFA and raised IR when compared to the Q1 group with lower level(P＜0.01),but the APN finding was the opposite(P＜0.01).After adjusting for other factors,APN,FFA,and IR were still associated with MS by using logistic regression analysis.Conclusions The level of FFA and state of IR was raised in subjects with MS,as well as with the increase in number of MS components,but the finding was the opposite as regard to APN.Serum APN,FFA,and IR may each play important roles in development of MS. Key words: Uygur ; Metabolic syndrome ; Adiponectin ; Free fatty acids ; Insulin resistance