Abstract
BackgroundThis study aimed to investigate the associations between metabolic syndrome (Mets) and adiponectin concentrations in Iranian adolescents.MethodsThis study was conducted as a sub-study of a national school- based surveillance program in 10–18 year- old students from 27 provinces in Iran. Plasma adiponectin was measured in 180 randomly selected participants. Metabolic syndrome (Mets) was defined based on the Adult Treatment Panel III (ATP- III) criteria modified for the pediatric age group. Multiple logistic regression analyses were used to evaluate the association between adiponectin and cardiometabolic risk factors.ResultsThe median of adiponectin concentrations was significantly lower among participants with Mets [2.95 μg/ml (interquartile range 2.72–3.30)] compared with subjects without Mets [4.55 μg/ml (interquartile range 3.02–5.75)]. Adiponectin showed significant negative association with higher number of Mets components (P- trend < 0.05). Significant correlations were observed between adiponectin concentrations and metabolic parameters, except blood pressure.Significant inverse association existed between adiponectin levels and presence of Mets (OR, 0.21; 95%CI: 0.10–0.45; p < 0.001). In multivariate models, this association remained significant after adjustment for other risk factors (OR, 0.18; 95%CI: 0.07–0.47; p < 0.001.ConclusionsAdiponectinhas inverse association with cardiometabolic parameters in Iranian adolescents, and it is a determinant of Mets independent of other risk factors. These findings can be used in comparison with other ethnic groups. Further longitudinal studies are necessary to assess the clinical impact of such inverse association.
Highlights
This study aimed to investigate the associations between metabolic syndrome (Mets) and adiponectin concentrations in Iranian adolescents
Studies suggest that cardiometabolic risk factors as well as obesity- related disorders are mediated through adipokines associated with obesity [9, 10]
Studies conducted in pediatric populations have documented that plasma adiponectin concentrations have an inverse correlation with body mass index (BMI), fasting insulin [11, 12], and seem to be associated with a range of Metabolic syndrome (Mets)’ components [13]. These findings suggest an etiologic role for low adiponectin levels in the pathophysiology of Mets [14]
Summary
This study aimed to investigate the associations between metabolic syndrome (Mets) and adiponectin concentrations in Iranian adolescents. Metabolic syndrome (Mets) is a cluster of cardiometabolic risk factors including abdominal obesity, dyslipidemia, hyperglycemia, and hypertension [1]. A growing body of evidence has shown that Mets increases cardiovascular disease (CVD) and all- cause mortality by 1.5–2 folds [2]. Adipokines, as adiponectin, are secreted by adipose tissue, which are associated with energy regulation, as well as glucose and lipid metabolism. Adiponectin has anti- inflammatory and anti- atherogenic effects and regulates metabolic homeostasis and vasodilatation, it increases insulin sensitivity [7, 8]. Studies suggest that cardiometabolic risk factors as well as obesity- related disorders are mediated through adipokines associated with obesity [9, 10]
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