Abstract
BackgroundSeveral studies have shown that Adenovirus 36 (Ad36) influences the risk of obesity in humans. Clarifying the relationship between Ad36 infection and obesity could lead to more effective approaches for the management of obesity. The objective of this study was to conduct a meta-analysis to confirm the influence of Ad36 infection on obesity and metabolic markers.Methodology/Principal FindingsWe searched MEDLINE and the Cochrane Library for pertinent articles (including their references) published between 1951 and April 22, 2012. Only English language reports of original observational studies were included in this meta-analysis. Data extraction was performed independently by two reviewers. Weighted mean differences (WMDs) and pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated using the random effects model. Of 237 potentially relevant studies, 10 cross-sectional studies (n = 2,870) conformed to the selection criteria. Pooled analysis showed that the WMD for BMI of Ad36 infection compared with non-infection was 3.19 (95% CI 1.44–4.93; P<0.001). Sensitivity analysis restricted to studies of adults yielded a similar result of 3.18 (95% CI 0.78–5.57; P = 0.009). The increased risk of obesity associated with Ad36 infection was also significant (OR: 1.9; 95% CI: 1.01–3.56; P = 0.047). No significant differences were found in relation to total cholesterol (P = 0.83), triglycerides (P = 0.64), HDL (P = 0.69), blood glucose (P = 0.08), waist circumstance (P = 0.09), and systolic blood pressure (P = 0.25).Conclusion/SignificanceAd36 infection was associated with the risk of obesity and weight gain, but was not associated with abnormal metabolic markers including waist circumstance. It suggests that Ad36 infection is more associated with accumulation of subcutaneous fat than that of visceral fat. The relationship between Ad36 and obesity should be assessed by further studies, including well-designed prospective studies, to gain a better understanding of whether Ad36 plays a role in the etiology of human obesity.
Highlights
Obesity has rapidly become a worldwide epidemic, with one billion people being either overweight or obese around the world [1]
Case-control studies, and cross-sectional studies evaluating the relation of obesity to Adenovirus 36 (Ad36) infection were considered eligible for inclusion if the following criteria were fulfilled: 1) the full text of report was published in English; 2) event numbers in each exposure category were reported; 3) the presence of Ad36 infection was reported; and 4) obesity events and/or body mass index (BMI) and other metabolic markers were reported
We identified a total of 237 reports by the database searches
Summary
Obesity has rapidly become a worldwide epidemic, with one billion people being either overweight or obese around the world [1]. Several recent studies have shown that Adenovirus 36 (Ad36) is associated with the risk of obesity and weight gain in humans [5– 14]. These studies have generally found a positive association of Ad36 infection with obesity, its magnitude has varied. Clarifying the relationship between Ad36 infection and obesity could lead to more effective approaches for the management of this condition. Clarifying the relationship between Ad36 infection and obesity could lead to more effective approaches for the management of obesity. The objective of this study was to conduct a meta-analysis to confirm the influence of Ad36 infection on obesity and metabolic markers
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