Association of Acyl-Ghrelin With Posttraumatic Stress Disorder in Adolescents Who Experienced Severe Trauma

Muhammad Omar Malik,Mohsin Shah,Ki Ann Goosens,Jocoll A Burgess,Muhammad Irfan Ul Akbar Yousufzai,Najeeb Ullah

doi:10.1001/jamanetworkopen.2020.13946

Abstract

Association of Acyl-Ghrelin With Posttraumatic Stress Disorder in Adolescents Who Experienced Severe Trauma

Highlights

Chronic stress, the occurrence of trauma and its adverse consequences over a prolonged period, is associated with the development of posttraumatic stress disorder (PTSD), even when many years have elapsed since the initial stress exposure.1 Acyl-ghrelin levels increase in rodents and humans during chronic stress exposure.2,3 Elevated acyl-ghrelin remains long after the primary stressful event ceases
Blood and saliva samples were collected for analyses of acyl-ghrelin and cortisol, respectively, and all participants were administered the PTSD CheckList– Civilian Version (PCL-C)
We observed an association between acyl-ghrelin and PTSD symptom severity in adolescents who experienced severe trauma

Summary

Introduction

The occurrence of trauma and its adverse consequences over a prolonged period, is associated with the development of posttraumatic stress disorder (PTSD), even when many years have elapsed since the initial stress exposure. Acyl-ghrelin levels increase in rodents and humans during chronic stress exposure. Elevated acyl-ghrelin remains long after the primary stressful event ceases (months in rodents, years in humans). The occurrence of trauma and its adverse consequences over a prolonged period, is associated with the development of posttraumatic stress disorder (PTSD), even when many years have elapsed since the initial stress exposure.. Acyl-ghrelin levels increase in rodents and humans during chronic stress exposure.. Elevated acyl-ghrelin remains long after the primary stressful event ceases (months in rodents, years in humans). Acyl-ghrelin, which is released mostly by the gut during times of energy depletion, is the only form of ghrelin that can bind to the ghrelin receptor. Stress-related increases in acyl-ghrelin underlie a long-term vulnerability to excessive fear.. We sought to determine whether elevated levels of acyl-ghrelin were associated with the development of PTSD or its severity in adolescents who experienced severe trauma Stress-related increases in acyl-ghrelin underlie a long-term vulnerability to excessive fear. Here, we sought to determine whether elevated levels of acyl-ghrelin were associated with the development of PTSD or its severity in adolescents who experienced severe trauma

Methods

Results

Conclusion