Abstract
CMV infections are acquired by 15-30% of infants hospitalized in intensive care nurseries (ICNs) for greater than 3 weeks. This study assessed the association of bronchopulmonary dysplasia (BPD) and acquired CMV infection in 54 infants <33 wks gestation and <1600 grams in one nursery. All infants had weekly urine cultures for CMV. 27 CMV(+) babies were matched with 27 CMV(−) babies for mean gestational age (28.5 wks vs. 29.1 wks), mean birth wt (1073 g vs. 1115 g), mean apgar scores (4.1/6.5 vs. 3.6/6.3), incidence of PDA (20/27 vs. 20/27) and incidence of RDS (19/27 vs. 18/27). The 27 CMV(+) babies were a mean age of 46.6 days (range 21-128 days) when they began to excrete CMV. CMV(+) infants received a mean of 18.9 random donor blood tranfusions vs. 10.5 for CMV(−) babies (p = .016). X-ray evidence of BPD was seen in 22/27 CMV(+) infants vs. 8/27 CMV(−) infants (p <.0001). CMV(+) infants required increased inspiratory O2 for a mean of 51.1 days vs. 21.6 days for controls (p = .006). These findings suggest that babies who acquire CMV while hospitalized in ICNs are more likely to have X-ray evidence of BPD and have increased O2 requirements. The acquisition of CMV by premature infants may contribute to the development of bronchopulmonary dysplasia.
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