Association of ABO Blood Groups with Cardiovascular Diseases in Adult Indian Population

Abstract

This study was designed to investigate whether there was an association between ABO blood groups and major cardiovascular diseases (ischemic heart diseases) in adult Indian population. The present retrospective study analyzed ABO blood groups among 1527 patients with documented IHD, who were treated at CIMS Hospital in Ahmedabad city from January to December, 2011 comparing with a control group of 860 subjects. Data were analyzed with GraphPad Prism 6.0 and by using chi square test. A p-value less than 0.05 were considered as +statistically significant. No significant difference in distribution of ABO blood groups was seen in patients with IHD (A, 21.95%; B, 35.41%; AB, 8.61%; O, 34.01%) and also after adjustment for common cardiovascular risk factors such as age, gender, addiction history, obesity, hypertension, diabetes in these patients (A, 25.47%; B, 37.53%; AB, 9.04%; O, 27.94%) as compared to the controls (A, 22.32%; B, 35.58%; AB, 8.83%; O, 33.25%), p-value = 0.9916 and 0.2778 respectively. The findings of the study suggest that there seems to be no correlation between various ABO blood groups and development of cardiovascular diseases. Moreover, the prevalence of major risk factors was equal in patients with different blood groups and blood groups had no impact on development of cardiovascular pathogenesis in individual subjects.