Abstract
Background. The objective of this study was to investigate the association of the ABO blood group phenotype and allele frequency with CHIK fever. Methods. A rural community survey in Southern Thailand was conducted in August and September 2010. A total of 506 villagers were enrolled. Cases were defined as individuals having anti-CHIK IgG by hemagglutination ≥1 : 10. Results. There were 314 cases (62.1%) with CHIK seropositivity. Females were less likely to have positive anti-CHIK IgG with odds ratio (OR) (95% CI) of 0.63 (0.43, 0.93). All samples tested were Rh positive. Distribution of CHIK seropositivity versus seronegativity (P value) in A, B, AB, and O blood groups was 80 versus 46 (0.003), 80 versus 48 (0.005), 24 versus 20 (0.55), and 130 versus 78 (<0.001), respectively. However, chi-square test between ABO and CHIK infection showed no statistical significance (P = 0.76). Comparison of the ABO blood group allele frequency between CHIK seropositivity and seronegativity was not statistically significant. Conclusion. This finding demonstrated no association of the ABO blood group phenotypes and allele frequencies with CHIK infection.
Highlights
Chikungunya (CHIK) is a disease caused by arthropod-borne viruses transmitted by Aedes mosquitoes
Compared with other arboviral diseases such as dengue disease, relatively few studies have been conducted in the host factors for CHIK infection
We conducted this study in three villages in Phatthalung province in Southern Thailand because they had the highest reported CHIK infection rate, 45.89 per 100,000 of population, in 2010
Summary
Chikungunya (CHIK) is a disease caused by arthropod-borne viruses transmitted by Aedes mosquitoes. Associations between the ABO blood group and various viral infections have been demonstrated, including dengue [6] and hepatitis C [7]. Results from genome-wide association studies (GWAS) suggest an association of the ABO blood group antigen with systemic inflammation [8, 9]. The objective of this study was to investigate the association of the ABO blood group phenotype and allele frequency with CHIK fever. Chi-square test between ABO and CHIK infection showed no statistical significance (P = 0.76). Comparison of the ABO blood group allele frequency between CHIK seropositivity and seronegativity was not statistically significant. This finding demonstrated no association of the ABO blood group phenotypes and allele frequencies with CHIK infection
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