Association of abdominal obesity with the development of fatal and non-fatal cardiovascular events in a cohort of rural residents of the Kyrgyz Republic: gender and ethnic characteristics

Abstract

Objective . To study the relationship of abdominal obesity (AO) with the development of fatal and non-fatal cardiovascular events among residents of the Chui region of the Kyrgyz Republic, taking into account gender and ethnicity. Design and methods . This study was carried out as part of the international epidemiological study “Interepid”. The total follow-up period was 7 years. Life status at the end of the follow-up was monitored in 1096 respondents out of 1341 initial cohorts (response 82,1%). Cases of fatal and non-fatal cardiovascular events were included as endpoints in the analysis. The frequency of events was assessed using methods of analysis of survival (Cox proportional hazard regression model, parametric survival models, Kaplan–Meier survival analysis). Results . 181 cases of fatal and non-fatal cardiovascular events (16,44%) were registered during the follow-up. A significant effect of AO on the incidence of cardiac complications in the analyzed cohort was demonstrated. Thus, in respondents with AO, the total frequency of cardiovascular events reached 21,31% and was significantly higher than in those without AO (10,69%, p < 0,0001). An increase in the frequency of events in the presence of AO was recorded in all analyzed subgroups (men, women, Russians, Kyrgyz). The construction of a Cox regression model with a logistic regression analysis made it possible to confirm the independent role of AO in the development of fatal and non-fatal cardiovascular events, which was most pronounced in women and respondents of the Kyrgyz ethnic group. At the same time, on average for the cohort, an increase in waist circumference value by 1 cm is accompanied by an increase in cardiovascular risk by 1,9%. Conclusions . The presence of AO is an independent risk factor for the development of fatal and non-fatal cardiovascular events in the analyzed cohort of residents of the Chui region, mostly among women and respondents of the Kyrgyz ethnic group.