Abstract
A recent study suggested that SLC35F3 which encoded a thiamine transporter was a new candidate gene for hypertension. The goal of this study was to investigate the association between the single-nucleotide polymorphisms (SNPs) in the SLC35F3 gene and hypertension in a Chinese population. Sanger sequencing was performed in 93 samples to find SNPs in coding regions and intron–exon boundaries in the SLC35F3 gene. We found eight genetic variants in the coding regions of SLC35F3 and subsequently genotyped a non-synonymous variant rs34032258 (C > G) in 1060 hypertension patients and 1467 controls. After adjusting for age and gender, multivariate analysis of covariance showed that the variant was associated with hypertensive traits. In detail, diastolic blood pressure (DBP) was 8 mmHg higher, blood urea nitrogen was 12 mmol/L higher, and creatinine was 15 mmol/L lower in G/G group compared with C/C group (p = 0.007; 0.012 and 0.029, respectively). Further study suggested that C/G+G/G had higher DBP than C/C genotype in those whose DBP ≥ 90 mmHg (98.02 mmHg vs. 94.04 mmHg, p = 0.021). No significant difference has been found in systolic blood pressure between different genotypes. Additionally, in the subgroup of obesity, allele distribution of this variant has shown significant difference between hypertensive patients and normotensive controls (p = 0.018). In conclusion, we found that the rs34032258 in the SLC35F3 gene was associated with high blood pressure and may increase the risk of hypertension. The new hypertension-susceptibility locus may involve in the pathogenesis of hypertension and indicate some novel treatment implications.
Highlights
The prevalence of hypertension is increasing in most countries and hypertension is an important risk factor for the development of cardiac-cerebral vascular diseases
We explored whether variants in the coding regions of the SLC35F3 gene contributed to blood pressure variation and hypertension
Zhang et al (2014) found that rs17514104 and rs16842784 in the SLC35F3 gene were associated with BP in subjects from North America and Western Europe, through the use of phenotypic extremes and genomic DNA pooling (Zhang et al, 2014)
Summary
The prevalence of hypertension is increasing in most countries and hypertension is an important risk factor for the development of cardiac-cerebral vascular diseases. Growing evidence showed that genetic and environmental factors played a crucial role in the onset of hypertension (Zhang et al, 2010; Munroe et al, 2011). According to single pressure value, SLC35F3 Gene and Hypertension the hypertensive heritability was 31–34%. Average value from more than three measurements showed a higher heritability of 56–57% and it could reach as high as 63–68% based on 24 h-ambulatory blood pressure monitory (Kupper et al, 2006). The heritable trait remains the most potent and crucial risk factor for cardiovascular diseases, details of its genetic determination are poorly understood (Munroe et al, 2011)
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