Abstract
BackgroundTreatment with steroids covers a wide spectrum of diseases in clinic. However, some users are suffering from serious side effects of steroid administration, while we enjoy the benefit it brings about. Osteonecrosis of the femoral head (ONFH) is a troublesome one among them. Recent studies have demonstrated that lipid metabolism disorder may play a vital role in pathogenesis of ONFH and mutation of the paraoxonase-1 (PON-1) gene may be involved in the occurrence of this disease. However, the relationship between polymorphisms of PON-1 and ONFH has not been thoroughly studied. The aim of this study was to determine whether PON-1 polymorphisms are associated with steroid-induced ONFH through a cohort study among Chinese Han population.MethodsThis trial applied a case–control scheme to compare the clinical data including PON-1 SNP among 94 patients and 106 control subjects to analyze the association between SNP and risk of steroid-induced ONFH. Time of Flight Mass Spectrometer is utilized for genotyping and the result was analyzed in multivariate analysis models.ResultsAccording to polymorphism test of rs662, its SNP was significantly associated with the risk of ONFH in overdominant analysis model [P value: 0.022; odds ratio (OR): 0.39]. However, genotype frequencies of rs662 of PON-1 gene between case and control group showed no differences (P > 0.05).ConclusionsOur data suggest for the first time that SNP (rs662) of the PON-1 gene was associated with the risk of steroid-induced ONFH. In addition, PAI-1 SNPs may play an important role in pathogenesis of ONFH.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticphatology.diagnomx.eu/vs/1501829501107336.
Highlights
Osteonecrosis of femoral head (ONFH) is a bone disease that cellular death happens within femoral head owing to damage of blood supply to the anterior–superior– lateral part of the femoral head [1]
More Male patient suffered from ONFH among these steroid users while more patients with relative less body mass index (BMI) developed ONFH
Polymorphism of rs662 was associated with the risk of steroid-induced ONFH The genotype frequency of rs662 polymorphism was in accordance with Hardy-Weinberg equilibrium in both case and control groups (Table 3)
Summary
Osteonecrosis of femoral head (ONFH) is a bone disease that cellular death happens within femoral head owing to damage of blood supply to the anterior–superior– lateral part of the femoral head [1]. Among ONFH caused by different etiologies, steroid-induced ONFH attracts vast attention for following reasons: first, there is a growing trend of its morbidity and some epidemic studies suggests it has became the leading cause of ONFH; Second, it typically happens in young patients that is the worst cases to handle; Last, preventative methods seems effective due to laboratory trial [4]. Perception of susceptible signs in patients on steroid medication is needed for its prospective benefits. To address this problem, the etiology and pathogenesis of ONFH must be thoroughly surveyed to find a starting point. Recent studies have demonstrated that lipid metabolism disorder may play a vital role in pathogenesis of ONFH and mutation of the paraoxonase-1 (PON-1) gene may be involved in the occurrence of this disease. The aim of this study was to determine whether PON-1 polymorphisms are associated with steroid-induced ONFH through a cohort study among Chinese Han population
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