Association of a maternal CD14 gene polymorphism with preterm premature rupture of membranes (PPROM) in multifetal pregnancies and its potentiation by interleukin-1 receptor antagonist (IL-1ra) and 70kDa heat shock protein (hsp70) gene polymorphisms

Abstract

CD14 is involved in induction of pro-inflammatory immunity. IL-1ra and hsp70 inhibit pro-inflammatory cytokine expression. We hypothesized that specific combinations of these polymorphic genes may differentially influence the rate of PPROM.