Abstract
Chronic obstructive pulmonary disease (COPD) is predisposed by environmental and hereditary factors”. A disintegrin and metalloproteinase 33 gene (ADAM33) has been one of the most stimulating gene for asthma since of their first association withthe disease in Caucasian population". "Recently,ADAM33 was shown to be associated with decrease of lung function andCOPD. The target of this study was to evaluate the potential correlation between polymorphisms of ADAM33 and COPD in Iraqi" population. This study included,400 cases of COPD and 400 healthy individuals as control group.“Two polymorphic loci (V4 and Q-1) of ADAM33 were selected for genotyping that determined by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. “Statistically significant distinctions in the distribution of the wild and mutant genotypes between patients and control. In addition,significant association (P <0. 0001) between COPD and mutant genotypes (V4/GG and Q-1/AA) are detected.The results of this study designate that ADAM33/V1 and Q-1 polymorphisms is a hazard factor for COPD among Iraqi society.
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