Abstract
Objectives: To study the link between frailty and cellular senescence, the authors examined the association of leukocyte telomere length (LTL) with a recently introduced measure of subclinical frailty that is based entirely on laboratory test biomarkers (FI-LAB). Methods: This study was conducted on a random sample of 1,890 Americans aged ≥60 years. Multiple linear regression was used to examine the relationship between FI-LAB and LTL. Secondary analyses were performed to identify the individual biomarkers driving the association between FI-LAB and LTL. Results: A statistically significant association was found between FI-LAB and LTL after adjusting for multiple covariates, indicating that higher FI-LAB scores are associated with shorter telomeres. Secondary analyses revealed that this association is driven largely by a small number of FI-LAB biomarkers independently linked with telomere shortening. Conclusion: The study results established a link between subclinical frailty (FI-LAB) and cellular ageing, which may help elucidate the pathophysiological mechanisms that give rise to frailty.
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