Abstract
Abstract Many studies have analyzed the relation about xeroderma pigmentosum group D (XPD) Lys751Gln polymorphism on esophageal cancer risk; however, the results were inconclusive. The present study was designed to assess the relationship in China. We searched the relevant articles from the databases of PubMed, Springer Link, Ovid, Chinese Wanfang Database, CNKI and Chinese Biology Medicine up to December 2019. An OR with the corresponding 95%CI was adopted to evaluate this association. This meta-analysis included 12 studies with 4195 esophageal cancer cases and 4762 controls. Overall, a positive association between XPD Lys751Gln and esophageal cancer risk was found in all the analysis model (Gln vs. Lys, OR= 1.26, 95% CI= 1.14-1.44; Gln/Gln vs. Lys/Lys, OR= 1.73, 95% CI= 1.29-2.31; Gln/Gln vs. Lys/Lys + Asp/Asn, OR= 1.63, 95% CI= 1.22-2.18; Gln/Gln+ Asp/Asn vs. Lys/Lys, OR= 1.25, 95% CI= 1.13-1.39). Subgroup analyses by geographic area and source of controls were further conducted; there was no substantial change in subgroup analyses. Our study suggested that XPD Lys751Gln polymorphism could increase the risk of esophageal cancer in China. Further studies in other ethnic populations are wanted to confirm these conclusions.
Highlights
Esophageal cancer is the sixth most common cause of cancer death in the world
The terms using in the analysis were as below: (“excision repair cross complementing group 2 (ERCC2)” or “XPD” or “xeroderma pigmentosum group D” or “excision repair cross-complementing group 2” or “DNA repair gene”) and (“esophageal” or “esophagus”)
We would select papers when they satisfied the following criteria: (1) case-control studies concentrating on the association about XPD Lys751Gln polymorphism on esophageal cancer risk, (2) including sufficient genetypes data which could calculate the odds ratio (OR), (3) studies reported in Chinese population, (4) human studies
Summary
Esophageal cancer is the sixth most common cause of cancer death in the world It is the fourth most common malignancy in China (Jemal et al, 2011; Vidal et al, 2020). In 2002, Xing et al (2002) firstly studied the relation about XPD Lys751Gln polymorphism on esophageal cancer risk in China. Many articles were published to explore the relationship between them in Chinese population, with inconsistent conclusions These different results may be caused by the studied population in different racial or regional and the small number of participants in every individual study. We designed this meta-analysis to explore more accurate association about XPD Lys751Gln polymorphism on esophageal cancer risk in China. Hierarchical analyses by geographic location and the source of controls were performed to further explore the association about XPD Lys751Gln polymorphism on esophageal cancer risk
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