Abstract
To investigate the association between xeroderma pigmentosum group D (XPD) Asp312Asn polymorphism and esophageal cancer (EC) susceptibility by meta-analysis. We searched PubMed up to April 9th, 2012, to identify relevant papers, and 8 published case-control studies including 2165 EC patients and 3141 healthy controls were yielded. Odds ratios (ORs) with relevant 95% confidence intervals (CIs) were applied to assess the association between XPD Asp312Asn polymorphism and EC susceptibility with the Comprehensive Meta-Analysis software, version 2.2. Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI=1.01-1.31, p=0.04]. In the subgroup analysis by ethnicity and cancer type, significantly associations were found for Caucasian populations [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.26, 95%CI=1.08-1.47, p<0.001; Asp/Asn vs. Asp/Asp: OR=1.19, 95%CI=1.02- 1.40, p=0.03] and esophageal squamous cell carcinoma [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.19, 95%CI=1.01-1.41, p=0.04]. There was no heterogeneity and no publication bias existed. This meta-analysis shows that the XPD Asp312Asn polymorphism may be a risk factor for developing EC, especially for Caucasian populations and esophageal squamous cell carcinoma.
Highlights
Esophageal cancer (EC) is one of the most common malignant diseases in an area that stretches from the Caucasian mountains to northern China, it is ranked as the eighth most common malignancy and the sixth most common cancer mortality worldwide (Umar et al, 2008)
Literatures search Initially we identified relevant studies which tested the association between XPD Asp312Asn polymorphism and EC susceptibility by searching the PubMed, using the following search terms: (“ERCC2” or “XPD” or “xeroderma pigmentosum group D” or “excision repair cross-complementing group 2” or “DNA repair gene”) and (“esophageal” or “esophagus”)
The XPD gene has been mapped to chromosome 19q13.3 and it is composed of 23 exons, and the XPD protein is involved in transcriptioncoupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex
Summary
Esophageal cancer (EC) is one of the most common malignant diseases in an area that stretches from the Caucasian mountains to northern China, it is ranked as the eighth most common malignancy and the sixth most common cancer mortality worldwide (Umar et al, 2008). Molecular researches provide genetic alteration is a novel risk factor of EC, that make individual more sensitive to carcinogen exposure (Lea et al, 2007). The genetic alteration s include aberrant cell cycle control, DNA repair, cellular enzymes, growth factor receptors, and nuclear receptors (Xu, 2009). Decreased efficiency of DNA repair is considered as a crucial role in carcinogenesis, as such defects accelerate genetic instability and the rate of genetic change (Hoeijmakers, 2001; Wood et al, 2001). The xeroderma pigmentosum group D (XPD) enzyme plays an important role in the repair of bulky DNA adducts, such as pyrimidine dimmers, photoproducts and cross-links (Hoeijmakers, 2001)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
