Abstract
BackgroundWNT1-inducible signaling pathway protein 1 (WISP1) is a member of the CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression may be involved in carcinogenesis. To date, no studies have investigated the association between single-nucleotide polymorphisms (SNPs) of WISP1 and gastric cancer. Therefore, we conducted this study to explore their relationship.MethodsPolymerase chain reaction-restriction fragment length polymorphism assay was used to analyze three SNPs of WISP1 in 204 gastric cancer patients and 227 controls.ResultsOverall, we could not identify a significant association between WISP1 SNPs and gastric cancer risk. However, the subgroup analysis demonstrated that the presence of the rs7843546 T allele was associated with a significantly decreased risk of gastric cancer in those of Han Chinese ethnicity (CT vs. CC: OR = 0.33, 95%CI 0.14–0.78; TT vs. CC: OR = 0.29, 95%CI 0.11–0.76; CT + TT vs. CC: OR = 0.32, 95%CI 0.14–0.74). In addition, patients with the rs7843546 TT genotype display a 0.34-fold lower risk of developing stage I/II gastric cancer than those with the CC genotype Furthermore, individuals ≥ 50 years old who carried the rs10956697 AC genotype had a significantly decreased risk of gastric cancer (OR = 0.58, 95%CI 0.35–0.98). Smokers with the rs10956697 AC and AC + AA genotypes exhibited a 0.28-fold lower and 0.32-fold lower risk of gastric cancer, respectively.ConclusionsThe WISP1 SNPs rs7843546 and rs10956697 were, for the first time, found to reduce susceptibility to gastric cancer in various subgroups of Guangxi Chinese.
Highlights
WNT1-inducible signaling pathway protein 1 (WISP1) is a member of the CCN protein family and a downstream target of β-catenin
There were no differences between the two groups in terms of smoking, drinking alcohol, or ethnicity
Our results revealed the correlations between WISP1 single nucleotide polymorphism (SNP)
Summary
WNT1-inducible signaling pathway protein 1 (WISP1) is a member of the CCN protein family and a downstream target of β-catenin. According to estimates from the World Health Organization (WHO), gastric cancer remains a commonly cancer worldwide and is responsible for 1,089,103 new cases and an estimated 768,793 deaths in 2020, ranking fifth for incidence and fourth for mortality globally [1]. China is a high-incidence region in terms of gastric cancer. The high incidence and mortality in China highlight the importance of understanding the risk factors related to gastric cancer development. Only about 1% people with Helicobacter infections will develop gastric cancer, likely because of differences in host genetics, gender, age of infection acquisition, alcohol consumption, tobacco smoking, and environmental factors [6]. More novel and powerful methods of identifying the predisposing genetic factors are expected to provide new insights regarding the basic molecular pathways involved in tumorigenesis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
