Abstract
BackgroundIn recent years, vitamin D in the occurrence of lung diseases has gradually become a hot topic. Although the role of vitamin D in normal lung development has been confirmed, the correlation between vitamin D level and neonatal respiratory distress syndrome (NRDS) is not clear.ObjectiveTo evaluate the association between vitamin D level and NRDS.MethodsWe performed a comprehensive search of the following electronic databases: PubMed, Embase, Cochrane Library, Web of Science, and China National Knowledge Infrastructure (CNKI). Literature screening and quality assessment were performed according to inclusion and exclusion criteria. The Newcastle–Ottawa Scale was used to assess the methodological components of each study, and Stata 15.1 software to perform the Meta-analysis.ResultsA total of nine case-control studies were included, with 653 infants with NRDS and 501 infants without NRDS. The Meta-analysis showed no heterogeneity across all studies(I2=0.0%, P=0.583). The fixed-effect model showed that 25 hydroxy vitamin D level of children in the NRDS group was significantly lower than that of the non-NRDS group(SMD = −0.51, 95%CI: −0.63 to −0.39, p ≤ 0.05).ConclusionThis systematic review and meta-analysis study suggests that vitamin D deficiency is very likely to be a high-risk factor of NRDS, and reasonable vitamin D supplementation during pregnancy and after birth is of great significance.
Highlights
Neonatal respiratory distress syndrome (NRDS), formerly known as hyaline membrane disease (HMD), is a clinical syndrome characterized by respiratory distress and progressive aggravation soon after birth [1], mostly due to insufficient pulmonary surfactant secreted by alveolar type II epithelial cells, which is more common in premature infants in clinical practice [2]
We assumed that vitamin D deficiency is associated with neonatal respiratory distress syndrome, for which we perform this meta-analysis to provide evidence-based medicine for the prevention and treatment of NRDS
Studies concerning the vitamin D level and NRDS were considered for inclusion
Summary
Neonatal respiratory distress syndrome (NRDS), formerly known as hyaline membrane disease (HMD), is a clinical syndrome characterized by respiratory distress and progressive aggravation soon after birth [1], mostly due to insufficient pulmonary surfactant secreted by alveolar type II epithelial cells, which is more common in premature infants in clinical practice [2]. With more and more in-depth research at home and abroad in recent years, many animal and laboratory studies have found that the lack of vitamin D is involved in the occurrence of respiratory diseases in children [7,8,9]. Some scholars have speculated that the occurrence of NRDS may be related to vitamin D deficiency, but this hypothesis has not been confirmed and elucidated. We assumed that vitamin D deficiency is associated with neonatal respiratory distress syndrome, for which we perform this meta-analysis to provide evidence-based medicine for the prevention and treatment of NRDS. Vitamin D in the occurrence of lung diseases has gradually become a hot topic. The role of vitamin D in normal lung development has been confirmed, the correlation between vitamin D level and neonatal respiratory distress syndrome (NRDS) is not clear
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