Abstract
In addition to biological actions of vitamin D such as calcium absorption, regulation of bone and mineral metabolism, studies have shown that Vitamin D is necessary for normal insulin secretion. Vitamin D influences insulin production and secretion through its effect on calcium and phosphorous metabolism. Vitamin D modifies insulin response by acting on receptor gene. Vitamin D deficiency has been implicated in decreased insulin secretion and increased insulin resistance. Objective: To measure and correlate vitamin D with fasting plasma glucose, HbA1c and fasting lipid profile in euglycemic individuals. Methods: Ethics clearance was obtained prior to data collection. After an overnight fast, blood samples were collected for fasting plasma glucose, lipid profile, HbA1c and vitamin D from euglycemic individuals who consented to participate. Vitamin D assay was estimated in Elecsys 2010 by ECLIA method. Plasma glucose was estimated by Hexokinase method. Serum fasting lipid profile was estimated in Cobas 6000 (Roche), and HbA1c measured using ion exchange HPLC method using Biorad Variant II turbo. Results: There was an inverse correlation between vitamin D and fasting plasma glucose (p＜0.001); Vitamin D and HbA1c (p＜0.001) in groups 1 and 3. There was also a significant inverse correlation of Total cholesterol (p=0.05), total cholesterol/HDL ratio (p＜0.001) with Vitamin D and significant direct correlation of HDL with vitamin D levels in groups 1 and 3. Conclusion: Deficiency of vitamin D can predispose to dysregulation of glucose and lipoprotein metabolism. There may be a role for vitamin D in better management of diabetes and dyslipidemia.
Highlights
The nature’s own product, an ancient hormone produced in the skin by sun exposure, is Vitamin D
In addition to biological actions of vitamin D such as calcium absorption, regulation of bone and mineral metabolism, studies have shown that Vitamin D is necessary for normal insulin secretion
Vitamin D reduces insulin resistance through regulation of the insulin receptor gene and its effects on calcium and phosphorous metabolism. (Nada AM 2013) Several studies have shown a role of vitamin D in insulin production, secretion and sensitivity. (Kositsawat JMDM et al 2010, Taheri E et al 2012, Maxwell CS and Wood RJ 2011) vitamin D deficiency has been implicated in decreased insulin secretion and increased insulin resistance which is the hallmark of type 2 diabetes mellitus
Summary
The nature’s own product, an ancient hormone produced in the skin by sun exposure, is Vitamin D. Animal studies have shown that Vitamin D is necessary for normal insulin secretion. (Nada AM 2013) Several studies have shown a role of vitamin D in insulin production, secretion and sensitivity. (Kositsawat JMDM et al 2010, Taheri E et al 2012, Maxwell CS and Wood RJ 2011) vitamin D deficiency has been implicated in decreased insulin secretion and increased insulin resistance which is the hallmark of type 2 diabetes mellitus. Type 2 diabetes mellitus and vitamin D deficiency have common predisposing factors such as obesity, less physical inactivity and ageing.(Rodriguez E et al.2009) Studies have shown vitamin D supplements in deficient individuals have resulted in improvement in insulin secretion and glucose tolerance. There is increasing evidence through many epidemiological studies that vitamin D deficiency was closely associated with increased risk of major adverse CVD events. There is increasing evidence through many epidemiological studies that vitamin D deficiency was closely associated with increased risk of major adverse CVD events. (Wang C 2013, Wang TJ et al 2008)
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