Abstract
Vitamin D deficiency is a growing health problem in both the general population and in patients with chronic kidney disease (CKD). However, the relationship between serum 25-hydroxyvitamin D levels and health-related quality of life in CKD is not well established. This study examined the association between vitamin D deficiency and quality of life in pre-dialysis CKD patients. Serum 25-hydroxyvitamin D levels and the Korean version of the Kidney Disease Quality of Life short form were obtained for 1844 pre-dialysis CKD patients in the prospective KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD). The baseline estimated glomerular filtration rate was 50.26 ± 0.71 mL/min/1.73 m2. We identified 1294 (70.2%) patients with vitamin D deficiency, defined as a 25-hydroxyvitamin D level < 20 ng/ml. The scores of the kidney disease component summary, physical component summary, and mental component summary in the vitamin D deficiency group were significantly lower compared to the scores of those without vitamin D deficiency. The serum 25-hydroxyvitamin D level was independently associated with the kidney disease component summary and mental component summary scores (β = 0.147, p = 0.003 and β = 0.151, p = 0.047). In conclusion, there was a significant association between serum 25-hydroxyvitamin D levels and kidney disease component summary and mental component summary scores in pre-dialysis CKD patients.
Highlights
Chronic kidney disease (CKD) is a major public health concern with rising prevalence
Health-Related Quality of Life (HRQOL) is a related concept that focuses on the effects of illness, and on the impact that treatment may have on quality of life (QOL)
The mean serum creatinine level was 1.83±0.03 mg/dl, and the mean eGFR calculated by the Modification of Diet in Renal Disease (MDRD) equation was 50.26±0.71 ml/min/1.73m2
Summary
Chronic kidney disease (CKD) is a major public health concern with rising prevalence. Health-Related Quality of Life (HRQOL) is a related concept that focuses on the effects of illness, and on the impact that treatment may have on QOL. Vitamin D plays an important role in the regulation of immune function [11, 12], and its deficiency was related with an increased rate of infection. Both infection and CKD-Mineral and Bone Disorders (MBD) affect the survival and hospitalization rates of patients with CKD, and vitamin D underlies both of these. We analyzed the correlation between vitamin D deficiency and HRQOL in CKD patients
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