Abstract
Pancreatic cancer is a devastating disease with poor prognosis. The association between vitamin A, retinol and carotenoid intake and the risk of pancreatic cancer occurrence remains controversial, and therefore it is necessary to make a meta-analysis to clarify the association between vitamin A, retinol and carotenoid intake and pancreatic cancer risk. In the present study, PubMed and EMBASE databases were used to identify qualified studies. The association between dietary vitamin A, retinol and carotenoids was estimated by pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs). It was found that there was an inverse correlation between vitamin A, beta-carotene and lycopene intake and the risk of pancreatic cancer (for vitamin A, pooled OR = 0.85, 95%CI = 0.74–0.97, P = 0.015; for beta-carotene, pooled OR = 0.78, 95%CI = 0.66–0.92, P = 0.003; for lycopene, pooled OR = 0.84, 95%CI = 0.73–0.97, P = 0.020), which was more prominent in case-control study subgroup. In conclusion, dietary vitamin A, beta-carotene and lycopene might inversely correlate with pancreatic cancer.
Highlights
3 studies were conducted in males only, 3 studies were in females only, and the other 16 in both sexes As for the nutrient type, 6 studies focused on Vitamin A, 11 on retinol, and 17 on carotenoids including 6 on alpha-carotene, 14 on beta-carotene, 8 on lycopene, 6 on crytoxanthin and 7 on lutein and zeaxanthin
The result showed that dietary vitamin A, carotene, beta-carotene and lycopene www.nature.com/scientificreports/ Figure 2
Provitamin A compounds, such as beta-carotene can transform into vitamin A, which is an essential molecule entailing multiple developmental pathways and influencing cell proliferation and differentiation in a variety of cell types[21]
Summary
Stratification analysis conducted by ethnicity and study design type revealed a significant association between vitamin A intake and pancreatic cancer risk in Caucasians subgroup (OR = 0.84, 95%CI = 0.73–0.96, P = 0.011) and case-control subgroup (OR = 0.83, 95%CI = 0.72–0.95, P = 0.007). The meta-analysis based on 11 studies of 9 articles indicated that there was no significant correlation between retinol intake and pancreatic cancer risk (OR = 1.02, 95%CI = 0.78–1.34, P = 0.860).
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