Abstract
Background: Some previous studies have shown reduced levels of plasma B-type natriuretic peptide (BNP) in individuals with obesity. We aimed to estimate the relationship between BNP and abdominal fat distribution, adjusted for confounding factors. Methods: This cross-sectional study included 1806 Japanese individuals (981 men and 825 women) who underwent a medical health check-up. Analyzed data included age, sex, visceral fat area (VFA), and subcutaneous fat area (SFA) as obtained from computed tomography, blood pressure, and blood test results including BNP. Multiple linear regression analysis was used to examine the association between BNP, VFA, and SFA after adjusting for age, sex, comorbidities, and body mass index. Results: In the models analyzed separately for VFA and SFA, BNP correlated independently with VFA in multiple linear regression analysis among all subjects and in both men and women, while SFA correlated inversely with BNP in all subjects and women but not in men. In the model that included both VFA and SFA, BNP correlated independently with VFA, but SFA and BNP were not correlated in any models. Conclusion: Higher VFA showed an independent, significant association with lower BNP. In addition, the inverse correlation with BNP was stronger for VFA than for SFA.
Highlights
B-type natriuretic peptide (BNP) is a peptide hormone secreted primarily by the ventricles, exerting diuretic effects, vasorelaxation, inhibitory effects on renin-aldosterone secretion, reduction of circulating plasma volume [1], and suppression of vascular smooth muscle and cardiac muscle hypertrophy and proliferation [2]
Metabolic syndrome (Mets) is a condition consisting of elevated blood pressure and impaired glucose and lipid metabolism based on visceral obesity
subcutaneous fat area (SFA) correlated inversely with BNP only in women (p = 0.003) but not when adjusted for visceral fat area (VFA) (p = 0.24). These results were unchanged in which the metabolic glucose disorder was replaced with homeostasis model assessment of insulin resistance (HOMA-IR) (Table 3)
Summary
B-type natriuretic peptide (BNP) is a peptide hormone secreted primarily by the ventricles, exerting diuretic effects, vasorelaxation, inhibitory effects on renin-aldosterone secretion, reduction of circulating plasma volume [1], and suppression of vascular smooth muscle and cardiac muscle hypertrophy and proliferation [2]. Insulin resistance [10,11,12], hyperinsulinemia [10,13], and Mets [6,12,14] have been inversely associated with BNP. Sex, visceral fat area (VFA), and subcutaneous fat area (SFA) as obtained from computed tomography, blood pressure, and blood test results including BNP. Multiple linear regression analysis was used to examine the association between BNP, VFA, and SFA after adjusting for age, sex, comorbidities, and body mass index. Results: In the models analyzed separately for VFA and SFA, BNP correlated independently with VFA in multiple linear regression analysis among all subjects and in both men and women, while SFA correlated inversely with BNP in all subjects and women but not in men. The inverse correlation with BNP was stronger for VFA than for SFA
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