Abstract
Aim Adult growth hormone deficiency (AGHD) is associated with an increased risk of fractures. The interactions between various body composition and bone are known to be complex in nature. However, very few studies have examined this crosstalk in AGHD. In this study, we sought to investigate the relationship between various parameters of body composition and bone mineral density (BMD) as well as determine the role of visceral fat in determining the bone mass in patients with AGHD. Methods We conducted a cross-sectional study on 57 patients with AGHD. Anthropometry, biochemistry, and analysis of body composition and BMD were performed according to standard protocols. Male and female patients were classified into those with osteoporosis and those without osteoporosis (normal subjects and patients with osteopenia). Further, we analyzed the correlation between the BMD and measurements obtained for various body composition parameters in male and female AGHD patients. Results Our findings indicated that among female AGHD patients, those with osteoporosis had a significantly higher levels of fat mass (FM) and visceral adipose tissue mass (VATM) (both, P < 0.05) than those without osteoporosis. Further, Pearson correlation analysis showed that the values of age, body mass index (BMI), FM, and VATM correlated negatively with BMD in women with AGHD (all P < 0.05); however, this association was not noted in men. After adjusting for the other covariates, VATM was found to be independently correlated with the BMD in female patients with AGHD. Conclusions A close correlation was noted between VATM and BMD in female patients with AGHD.
Highlights
Osteoporosis is a metabolic bone disease that is characterized by decreased bone mass and a high risk of fracture, even after relatively minor falls [1]
Evidence has shown that body fat may have different effects on the Bone mineral density (BMD), depending on the region of deposition; this regional variation in the manner in which fat mass influences bone density may be attributed to the differences in the effects of subcutaneous fat and visceral adipose tissue (VAT) on bones
® (Hologic Discovery QDR Series, Bedford, MA, USA), which is a reliable tool for detecting osteoporosis. e device used was calibrated every morning, and its coefficient of variation (CV) for bone measurements was less than 1%
Summary
Linman Li ,1 Li Zhong, Xiaoya Zheng, Wenyi You ,3 Yunting Wang, Jihui Yu, Xun Wu, Wei Ren ,2 and Gangyi Yang 4. We sought to investigate the relationship between various parameters of body composition and bone mineral density (BMD) as well as determine the role of visceral fat in determining the bone mass in patients with AGHD. We analyzed the correlation between the BMD and measurements obtained for various body composition parameters in male and female AGHD patients. Pearson correlation analysis showed that the values of age, body mass index (BMI), FM, and VATM correlated negatively with BMD in women with AGHD (all P < 0.05); this association was not noted in men. After adjusting for the other covariates, VATM was found to be independently correlated with the BMD in female patients with AGHD. A close correlation was noted between VATM and BMD in female patients with AGHD
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