Abstract
Visceral adiposity index (VAI) is a mathematical index derived from the body mass index (BMI), waist circumference (WC), serum fasting triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C). It reflects visceral adipocyte dysfunction (VAD) and is associated with cardiometabolic risk. Women with polycystic ovarian syndrome (PCOS) have adipocyte dysfunction, which is associated with metabolic disorders. Hirsutism in PCOS is considered to be due to high insulin levels which enhances androgen activity at the pilosebaceous unit. To determine the association between VAI, hirsutism and cardiometabolic risk factors in patients with PCOS. A total of 99 patients aged 18-40 years with PCOS diagnosed by the Rotterdam consensus criteria-2003 and a hirsutism score of 8 or more according to the Ferriman-Gallway Score (FGS) were studied. BMI, WC, fasting lipid profile, serum leptin, insulin, sex hormone binding globulin (SHBG), free-androgen index (FAI), fasting blood glucose (FBG) and oral glucose tolerance test (OGTT) were determined. Homeostasis model assessment (HOMA)-beta, HOMA-insulin resistance (IR) and VAI were calculated. Diameter and rate of hair growth at sideburns and chin; density of hair at sideburns were measured. Data were analyzed by SPSS-22.0. There was no significant association between parameters of hirsutism and VAI. There was a significant association between VAI and OGTT, FAI, systolic and diastolic blood pressure: but not between VAI and other metabolic parameters. Visceral adipocyte dysfunction is closely linked to glucose intolerance and blood pressure in women with PCOS. However, hirsutism is unlikely to be due to adipocyte dysfunction.
Highlights
Visceral adiposity index (VAI) is a mathematical index derived from the body mass index (BMI), waist circumference (W C), serum fasting triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C)
A total of 99 patients aged 18-40 years with polycystic ovarian syndrome (PCOS) diagnosed by the Rotterdam consensus criteria2003 and a hirsutism score of 8 or more according to the Ferriman-Gallway Score (FGS) were studied
There was no significant association between parameters of hirsutism and VAI
Summary
Visceral adiposity index (VAI) is a mathematical index derived from the body mass index (BMI), waist circumference (W C), serum fasting triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C). It reflects visceral adipocyte dysfunction (VAD) and is associated with cardiometabolic risk. High visceral adipose tissue is associated with visceral adipocyte dysfunction which is characterized by an altered insulin sensitivity, lipolytic activity, a proinflammatory state and release of adipocytokines [1, 2]. Adipocyte dysfunction leads to a rise in adipocytokines such as leptin, adiponectin, tumor necrosis factor-alpha and resistin [4] This provides an objective index of the extent of adipose tissue dysfunction [5]. The quantitative analysis of visceral and cutaneous fat is carried out via MRI (Magnetic Resonance Imaging) or CT (Computed Tomography) and remain the gold standard for assessment of visceral adipose tissue though rather expensive and not routinely used in clinical practice [7]
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