Abstract
PurposeVascular endothelial growth factor (VEGF) contributes to the development of retinopathy of prematurity (ROP). A number of studies investigated the association of ROP with VEGF −460 T/C and +936 C/T polymorphisms but the results were conflicting. In order to derive a more precise estimation of the associations, we performed a meta-analysis of the relationship between VEGF −460 T/C and +936 C/T polymorphisms with ROP in all published studies. MethodsA literature search was performed systematically using electronic databases. Published literature from PubMed and other databases was retrieved. The odds ratio (OR) with 95% confidence interval (CI) was used to estimate the pooled effect. Each −460 T/C and +936 C/T polymorphism included four case-control studies including case/control 249/308 and 179/250 respectively. ResultsThrough literature search, we found that both VEGF −460 T/C and +936 C/T polymorphisms were not associated with ROP risk at allelic, co-dominant, dominant and recessive models. ConclusionsThis meta-analysis suggests that the VEGF −460 T/C and +936 C/T polymorphism might contribute to genetic susceptibility of ROP. The association between VEGF −460 T/C and +936 C/T polymorphism and ROP risk awaits further investigation.
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