ASSOCIATION BETWEEN URIC ACID AND METABOLIC SYNDROME IN HYPERTENSIVE PATIENTS

Abstract

Objective: Obesity and metabolic syndrome are implicated in the pathophysiology of hypertension. The aim of this work is to analyse the association between uricemia and components of the metabolic syndrome and insulin resistance in hypertensive patients. Design and method: It is a prospective study, 245 hypertensive patients (57 ± 8.49 years: women (79,60%)/ men (20,40%), 115 patients with MetS and 130 without MetS were examined for metabolic status in fasting blood (glycemia, triglycerides,total cholesterol, HDLc, LDLc, uric acid, CRPus and HOMA-IR. The definition of the National Cholesterol Education Program Adult Treatment Panel III for Mets. Insulin resistance estimated by the HOMA-IR. Results: The prevalence of metabolic syndrome in our series is 48%, we observed that 45% of patients are sedentary, 47% are overweight and 36.25% of them are obese. Insulin resistance assessed by the HOMA index is 45%. The results of the uricemia in the patients reveal levels of (51.81 ± 13.8) mg/l for the HTA with sMet, and 45.73 ± 13.7 for the group without sMet. It is higher in obese hypertensive patients, the difference is significant (p = 0.0005). Correlation analysis between uric acid and components of the metabolic syndrome revealed a significant association with BMI (p = 0.003), waist circumference (p = 0.0006), HOMA-IR (p = 0.0006) and CRPus (p = 0.04) in the sMet group. In the group without sMet no significant correlation was found with the parameters studied. Conclusions: The data obtained in our series reveal that hyperuricemia could be a cardiovascular risk factor. Several experimental and epidemiological studies also support a direct or indirect role of hyperuricemia in the pathogenesis of the metabolic syndrome in hypertension.