Abstract
ObjectiveTo investigate the relationship between uric acid and metabolic syndrome (MetS) in elderly women.MethodsA total of 468 women aged ≥60 years participating in a health examination were enrolled. The association between uric acid and MetS and its individual variables was evaluated by univariate and multivariate logistic regression models.ResultsA dose-response relationship was observed for the prevalence of MetS and uric acid quartiles. Subjects in the second, third and fourth quartile of uric acid had a 2.23-fold, 2.25-fold and 4.41-fold increased risk, respectively, of MetS than those in the first uric acid quartile (p for trend <0.001). Furthermore, each 1 mg/dl increment of serum uric acid level had a 1.38-fold increased risk of MetS (OR 1.38; 95% CI, 1.14-1.69; p=0.001).ConclusionsOur present study demonstrated that elevated uric acid was positively associated with the prevalence of MetS in elderly women. Further random control trials are needed to elucidate the effectiveness of treatment of hyperuricaemia in reducing the incidence of MetS in elderly women.
Highlights
MethodsA total of 468 women aged ≥60 years participating in a health examination were enrolled
Our present study demonstrated that elevated uric acid was positively associated with the prevalence of metabolic syndrome (MetS) in elderly women
MetS is associated with increased risk of type 2 diabetes mellitus (DM), cardiovascular disease, cardiovascular mortality and all-cause mortality [2, 3], and is regarded as a critical public health and clinical challenge given its high prevalence in developing and developed countries [4, 5]
Summary
A total of 468 women aged ≥60 years participating in a health examination were enrolled. The association between uric acid and MetS and its individual variables was evaluated by univariate and multivariate logistic regression models. Our present study enrolled 468 Han Chinese elderly women (aged 60-90 years) who visited for an annual health examination in Linyi People’s Hospital from March 2016 to October 2016. Association between uric acid and metabolic syndrome in elderly women 173. Trained nurses administered standardized questionnaires to obtain general information, including age, past illness history, history of drug treatment, smoking, drinking, etc. Waist circumference (WC) was measured between the iliac crest and rib cage with a non-elastic tape. Blood pressure was measured 3 times with an automated sphygmomanometer in the seated position after at least 5 minutes of rest
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