Abstract
The objective of our study was to evaluate the effects of upper-airway surgery on improvement of endothelial function-related markers in patients with obstructive sleep apnea (OSA). Subjects with moderate to severe OSA who underwent upper-airway surgery, with a follow-up duration of at least 6 months, were included. Pre- and postoperative polysomnographic variables and endothelial function-related markers were compared. Subgroup and correlation analyses were conducted to find possible indicators for better endothelial function-related markers after upper-airway surgery. In total, 44 patients with OSA were included. The mean follow-up duration was 1.72 ± 0.92 years. Serum VEGFA [−20.29 (CI: −35.27, −5.31), p < 0.05], Ang2 [−0.06 (CI: −0.16, 0.03), p < 0.05], E-selectin [−7.21 (CI: −11.01, −3.41), p < 0.001], VWF [−58.83 (CI: −103.93, −13.73), p < 0.05], VWFCP [−33.52 (CI: −66.34, −0.70), p < 0.05], and TM [−0.06 (CI: −0.09, −0.03), p < 0.05] were significantly lower after upper-airway surgery. However, other risk markers of endothelial function, such as Ang1, ICAM1, VEGFR1, and VCAM, did not change significantly. Correlations between improved endothelial function-related markers and ameliorated oxyhemoglobin saturation and glucolipid metabolism were established. Upper-airway surgery might be associated with an improvement in endothelial function in patients with OSA. These changes may be associated with improved oxygen saturation after upper-airway surgery.
Highlights
Prospective studies have revealed that continuous positive airway pressure (CPAP) reduces cardiovascular risk in patients with OSA2,9
We comprehensively analyzed the associations between upper-airway surgery and changes in endothelial cell (EC) dysfunction-related cytokines, including angiogenesis-related cytokines[14,15]: VEGFA, VEGF receptor 1 (VEGFR1), angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2); CAMs16: ICAM-1, vascular cell adhesion molecule (VCAM)-1 and E-selectin; and coagulation function-related cytokines[17,18]: VWF, von Willebrand factor cleavage protease (VWFCP), and thrombomodulin (TM)
We found that upper-airway surgery can lead to significant improvements in the levels of endothelial function-related markers, including VEGFA, Ang[2], E-selectin, VWF, VWFCP, and TM
Summary
Prospective studies have revealed that continuous positive airway pressure (CPAP) reduces cardiovascular risk in patients with OSA2,9. Previous research has revealed that upper-airway surgeries are associated with improved cardiometabolic biomarkers and even overall cardiovascular risk[12,13] It is still not clear whether upper-airway surgeries aimed at solving oropharyngeal and retrolingual plane obstruction could be associated with disorders of representative vascular biological function markers triggered by OSA-related pathological factors. We comprehensively analyzed the associations between upper-airway surgery and changes in EC dysfunction-related cytokines, including angiogenesis-related cytokines[14,15]: VEGFA, VEGF receptor 1 (VEGFR1), angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2); CAMs16: ICAM-1, VCAM-1 and E-selectin; and coagulation function-related cytokines[17,18]: VWF, von Willebrand factor cleavage protease (VWFCP), and thrombomodulin (TM)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
