Abstract
BACKGROUND: Type 2 innate lymphoid cells (ILC2s) were shown to be involved in Th2-type immune responses in allergic disease animal models. ILC2s enrichment was shown in nasal polyps in chronic rhinosinusitis (CRS) patients and peripheral blood from asthma animal models; the role of ILC2s9 contribution of Th2 response in CRS and asthma remains to be investigated. AIMS: We hypothesized that there would be enhanced expression of ILC2s in peripheral blood of patients with CRS and asthma, which may show correlation with clinical features. METHODS: 6 CRS patients ,5 Asthma patients 5 healthy controls were recruited in our out-patient allergy clinic , ILC2 were quantized as Lin-CRTH2+CD127+ from PBMSs of subjects by using flowcytometry. SNOT-20 , VAS score and levels of IgE were also documented.IL-5 and IL-10 were measured in serum samples from patients by ELISA RESULTS: There were higher IC2 ratio (number of IC2s / one million PBMC %) in CRS group(0.958 ± 0.6209) and Asthma group(1.1191 ± 0.2611) , ,compared to healthy control(0.4831 ±0.0564).(p CONCLUSIONS: Our results showed the IL2s ratio were correlated with clinical features of allergic airway patients, type 2 innate immune responses were higher in CRS and asthma,ILC2 maybe a good marker of airway eosinophilic inflammation and peripheral blood is useful for evaluating type 2 innate immunity in human.
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