Abstract
ObjectiveThe purpose of this study was to explore the association between the TNF-α rs1800629 (also refers as -308G/A) polymorphism and asthma susceptibility.MethodsWe searched the Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.ResultsA total of 34 studies involving 5477 asthma patients and 5962 controls were included in present study. The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21–1.76, P<0.0001). Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48–4.12, P = 0.0005; OR = 1.83, 95% CI = 1.42–2.36, P<0.00001), but not East Asians and Caucasians. Furthermore, significant association also was observed in allergic asthma (OR = 1.51, 95% CI = 1.24–1.83, P<0.0001), adults and children (OR = 1.43, 95 CI% = 1.07–1.91, P = 0.02; OR = 1.57, 95% CI = 1.19–2.06, P = 0.001).ConclusionsThis meta-analysis suggested that the rs1800629 polymorphism in TNF-α was a risk factor for asthma.
Highlights
Asthma is a chronic allergic disorder of the airways that is characterized by inflammatory infiltrates in the bronchial walls, airway hyperresponsiveness (AHR) and reversible airway obstruction [1]
The results indicated that tumor necrosis factor-alpha (TNF-a) rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% confidence intervals (CIs) 1.21–1.76, P,0.0001)
Subgroup analyses found that the TNF-a rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48–4.12, P = 0.0005; odds ratio (OR) = 1.83, 95% CI = 1.42–2.36, P,0.00001), but not East Asians and Caucasians
Summary
Asthma is a chronic allergic disorder of the airways that is characterized by inflammatory infiltrates in the bronchial walls, airway hyperresponsiveness (AHR) and reversible airway obstruction [1]. Numerous risk genes have been reported to be associated with asthma susceptibility in various populations [3]. One of the candidate susceptible genes which has been intensely investigated is tumor necrosis factor-alpha (TNF-a). A meta-analysis performed by Chen et al demonstrated that TNFa antagonism therapy was superior to control therapy in preventing exacerbations in patients with asthma [6]. These accumulated data support the idea that TNF-a plays an important role in the pathogenesis of asthma and the TNF-a gene may be a susceptibility gene of asthma
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