Abstract
The association of thyrotropin (TSH) with overall (body mass index, BMI), visceral (waist circumference and steatosis), and upper subcutaneous (neck circumference, NC) adiposity markers is still controversial, and the aim of this study is to assess these associations in the baseline data of a large cohort from ELSA-Brasil. This cross-sectional study included 11,224 participants with normal thyroid function (normal TSH levels). BMI, waist circumference, NC and steatosis, defined by hepatic attenuation (mild or moderate/severe) were the explicative variables. TSH levels were log transformed (logTSH), and multivariate linear regression models were generated to estimate the associations between logTSH and BMI (continuous and categorized), waist circumference, NC, and steatosis after adjusting for sociodemographic characteristics, health behaviors, and comorbidities. The mean age was 51.5±8.9 years, 5,793 (51.6%) participants were women, 21.8% (n = 2,444) were obese, and 15.1% of the sample was TPOAb positive. The TSH levels were significantly higher in the obese group than in the reference group (<25.0 kg/m2). In the multivariable linear regression models, significant associations of logTSH with BMI and obesity were found. LogTSH was associated with waist circumference only among women. NC and steatosis were not related to TSH levels. TSH levels were associated with overall adiposity and obesity. Further studies may elucidate reference levels of TSH according to BMI status.
Highlights
Thyrotropin (TSH) is a well-recognized pituitary hormone that binds to its receptor on the thyroid gland, promoting thyroid function
Further studies may elucidate reference levels of TSH according to body mass index (BMI) status
Among BMI categories, TSH levels were significantly higher in the obesity group than in the reference group (
Summary
Thyrotropin (TSH) is a well-recognized pituitary hormone that binds to its receptor on the thyroid gland, promoting thyroid function. Treatment of subclinical hypothyroidism does not seem to be beneficial for weight loss purposes.[5] A systematic review that included 29 studies showed an association between TSH and adiposity markers, such as body mass index (BMI) and waist circumference among individuals with normal thyroid function in 18 studies,[6] even independently of free thyroxine levels.[7] among these studies, some adjusted for smoking status[7,8,9,10,11,12,13,14,15,16,17] and others do not. The association of thyrotropin (TSH) with overall (body mass index, BMI), visceral (waist circumference and steatosis), and upper subcutaneous (neck circumference, NC) adiposity markers is still controversial, and the aim of this study is to assess these associations in the baseline data of a large cohort from ELSA-Brasil
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