Association between Triglyceride and glycose (TyG) index and subclinical myocardial injury

Abstract

Background and aimsTriglyceride and glycose (TyG) index has been viewed as a reliable surrogate of cardiovascular disease (CVD) risk. We hypothesized that elevated TyG index is associated with increased risk of subclinical myocardial injury (SC–MI). Methods and resultsA total of 6093 participants without history of CVD were extracted from the third National Health and Nutrition Examination Survey (NHANES III). SC–MI was defined by cardiac infarction/injury score (CIIS) ≥10. Multivariate logistic regression was performed to examine the association between TyG index (as a qualitative or quantitative variable) and SC–MI. TyG index was positively correlated with CIIS (β = 0.54; p = 0.004) in the multivariable linear regression analysis. In a multivariable model, TyG index was independently associated with an increased risk of SC–MI (OR = 1.17, 95% CI: 1.05 to 1.30; p = 0.004). Also, TyG>9.00 increased the risk of SC–MI (OR = 1.21, 95% CI: 1.03 to 1.43; p = 0.024) independent of other risk factors. ConclusionElevated TyG index increases the risk of CIIS and SC–MI, which could be a new biomarker in the clinical practice.