Association between triclosan levels and white blood cell counts in US adults from NHANES, 2011–2012

Abstract

Triclosan is a broad-spectrum antimicrobial agent used in a multitude of healthcare and consumer products. Epidemiological studies link triclosan exposure to several adverse health outcomes including alterations in thyroid function and an increased risk for allergies and asthma suggesting an immunomodulatory role for the endocrine disrupting synthetic chemical. The effects of triclosan on the human immune system, particularly on the levels and function of white blood cells, have yet to be fully characterized. Using cross-sectional data from the NHANES 2011–2012 survey, we examined the relationship between triclosan exposure levels and white blood cell counts in adults 18–65 years of age. Results from multivariable linear regression analysis show lack of a statistically signficant association between urinary triclosan levels and white blood cell counts (β = −0.0007, p = 0.90, 95% CI = −0.012, 0.010). Findings may demonstrate an absence of association or may indicate that triclosan exposure levels were too low to have a significant detectable impact on white blood cell counts. Considering that prior animal and epidemiological studies have established links between triclosan exposure and alterations in immune system parameters and susceptibility to allergic diseases, the effects of triclosan exposure on the immune system should continue to be evaluated.