Association between triclosan and obesity using NHANES 2007-2016: Overall and stratified population

Abstract

Studies have shown that triclosan is able to exert estrogenic activity and may affect energy metabolism through multiple mechanisms, which in turn is associated with obesity and overweight. However, insufficient research has been done to confirm its connection to obesity in the general population. This study's aim was to explore the relationship between triclosan and obesity in American adults (aged 20). The association was further explored in populations stratified by sex, age, race, education level, and socioeconomic status. In the general population, there was a connection between triclosan and obesity that was detrimental. (OR: 0.97, 95% CI: 0.95-0.99, p value: 0.017).In the other race group, triclosan and obesity were found to be dramatically negatively correlated (including multi-racial) when stratified by race (OR: 0.89, 95% CI: 0.8-0.98, p value: 0.019). When stratified by socioeconomic class, there was a substantial relationship between triclosan and obesity in the above poverty group. (OR: 0.97, 95% CI: 0.94-1, p value: 0.023). Finally, when dividing the population according to education level, we had a more novel finding in the graduate or above group: it was discovered that triclosan lowers the likelihood of obesity (OR: 0.92, 95% CI: 0.88-0.98, p value: 0.005) while increasing odds of overweight (OR: 1.06, 95% CI: 1.01-1.11, p value: 0.027).