Association between total antioxidant capacity and mortality in ischemic stroke patients.

Leonardo Lorente,Juan J Cáceres,Luis Ramos,Jordi Solé-Violán,María M Martín,Alejandro Jiménez,Mónica Argueso,Pedro Abreu-González,Antonia Pérez-Cejas

doi:10.1186/s13613-016-0143-7

Abstract

ObjectiveData on circulating total antioxidant capacity (TAC) levels in ischemic stroke patients compared with healthy controls are limited and provided conflicting findings. There are not data about the association between circulating TAC levels, peroxidation state and outcome in patients with severe ischemic stroke. The objective of this study was to examine the relationship of TAC with 30-day mortality after severe ischemic stroke.Methods This multicenter study included 58 patients with coma (Glasgow Coma Scale < 9) following severe malignant middle cerebral artery infarction (MMCAI). We measured circulating levels of TAC and malondialdehyde (MDA, a biomarker of lipid peroxidation) on day 1 of severe MMCAI diagnosis. The study endpoint was 30-day mortality.ResultsNon-survivors (n = 29) showed higher serum TAC levels (p < 0.001) and higher serum MDA levels (p = 0.004) than survivors (n = 29). Multiple binomial logistic regression analysis showed that serum TAC levels were associated with 30-day mortality, after controlling for Glasgow Coma Scale and age (odds ratio 1.92; 95 % confidence interval 1.201–3.072; p = 0.006). There was a correlation between serum TAC and MDA levels (rho = 0.35; p = 0.008).ConclusionsThis single-center study in severe MMCAI patients found an association between higher serum TAC levels and 30-day mortality and further identified a relationship between serum TAC levels, lipid peroxidation state and mortality after severe ischemic stroke.

Highlights

Ischemic stroke leads to substantial disability, mortality and consumption of resources [1]
Intensive Care (2016) 6:39 objective of this study was to determine whether there is an association between circulating total antioxidant capacity (TAC) levels, peroxidation state and mortality in patients with severe malignant middle cerebral artery infarction (MMCAI)
We found that the area under the curve (AUC) for serum TAC levels as predictor of 30-day mortality was of 0.82 (Fig. 3)

Summary

Introduction

Ischemic stroke leads to substantial disability, mortality and consumption of resources [1]. Circulating TAC in ischemic stroke patients has been scarcely studied, and the findings are conflicting [10,11,12,13,14,15]. In another study was found higher circulating TAC in ischemic stroke patients than in healthy control subjects [15]. There are not data about the association between circulating TAC levels, peroxidation state and mortality in patients with ischemic stroke. The Lorente et al Ann. Intensive Care (2016) 6:39 objective of this study was to determine whether there is an association between circulating TAC levels, peroxidation state and mortality in patients with severe malignant middle cerebral artery infarction (MMCAI)

Methods

Results

Discussion

Conclusion