Association between tirofiban monotherapy and efficacy and safety in acute ischemic stroke

Chunrong Tao,Wenwu Luo,Xiaodong Yuan,Jianlong Song,Jie Liu,Wei Hu,Changchun Chen,Chao Zhang,Tianlong Liu,Yuanyuan Zhu,Dezhi Liu,Yuyou Zhu

doi:10.1186/s12883-021-02268-8

Abstract

BackgroundStudies have suggested that glycoprotein IIb/IIIa antagonists such as tirofiban are beneficial for patients with acute coronary syndromes. However, it is still uncertain about the efficacy and safety of tirofiban in patients with acute ischemic stroke (AIS).MethodsIn this prospective non-randomized study, 255 AIS patients were recruited from 4 comprehensive stroke centers in China between January, 2017 and May, 2018. Among them,169 patients were treated with aspirin plus clopidogrel and 86 patients were treated with tirofiban. The primary functional outcome was the distribution of the 90 days’ modified Rankin Scale (mRS). The safety outcomes included the incidence of intracranial hemorrhage (ICH) at discharge and mortality at 3 months.ResultsIn the propensity score matched cohort, tirofiban alone was noninferior to the dual antiplatelet with regard to the primary outcome (adjusted common odds ratio, 0.97; 95% confidence interval, 0.46 to 2.04; P = 0.93). Mortality at 90 days was 10% in the dual antiplatelet group and 8% in the tirofiban group (adjusted odds ratio 0.75; 95% CI 0.08 to 7.40, p = 0.81). There was no difference of the ICH rate between two groups (adjusted odds ratio 0.44; 95% CI 0.13 to 1.48, p = 0.18). In the inverse probability of treatment weighting-propensity score-adjusted cohort, similar differences were found for functional and safety outcomes.ConclusionsOur study suggested that tirofiban use appears to be safe as monotherapy in AIS treatment compared with common dual antiplatelet therapy, however, no improvement in functional outcomes was found.Trial registrationChinese clinical trial registry, ChiCTR2000034443, 05/07/2020. Retrospectively registered.

Highlights

Studies have suggested that glycoprotein IIb/IIIa antagonists such as tirofiban are beneficial for patients with acute coronary syndromes
Only few studies have evaluated the efficacy of tirofiban and some of them primarily focused on the efficacy of tirofiban in patients receiving Intravenous thrombolysis (IVT) or endovascular treatment (EVT) [9, 10]
169 patients were treated with aspirin plus clopidogrel and 86 patients were treated with tirofiban

Summary

Introduction

Studies have suggested that glycoprotein IIb/IIIa antagonists such as tirofiban are beneficial for patients with acute coronary syndromes. It is still uncertain about the efficacy and safety of tirofiban in patients with acute ischemic stroke (AIS). Intravenous thrombolysis (IVT) with alteplase is the preferred therapy for patients with acute ischemic stroke (AIS) [2]. Other treatment options are in demand for the AIS patients who could not receive IVT within the time window. As a highly selective nonpeptide gpIIb/IIIa antagonist, tirofiban has been proven to be beneficial for the treatment of acute coronary syndrome [6]. Only few studies have evaluated the efficacy of tirofiban and some of them primarily focused on the efficacy of tirofiban in patients receiving IVT or endovascular treatment (EVT) [9, 10]

Methods

Results

Conclusion