Abstract
Thyroid dysfunction has been implicated as a potential pathophysiological factor in glucose homeostasis and insulin resistance (IR). This study aimed to identify the correlation between thyroid dysfunction and IR. We used data from the sixth Korean National Health and Nutrition Examination Survey to evaluate a total of 5727 participants. The triglyceride glucose (TyG) index and homeostasis model assessment of insulin resistance (HOMA-IR) were calculated to represent IR. Correlation analysis was performed between thyroid dysfunction and IR. The log-transformed TSH (LnTSH) and free T4 were significantly correlated with the TyG index (TSH, beta coefficient 0.025, 95% confidence interval [CI] 0.014–0.036, p < 0.001; free T4, − 0.110 (− 0.166 to − 0.054), p < 0.001) but not HOMA-IR. Overt hypothyroidism is correlated with increased TyG index in pre-menopausal females (0.215 (0.122–0.309) p < 0.001). On the other hand, overt hyperthyroidism is correlated with increased HOMA-IR in males (0.304 (0.193–0.416), p < 0.001) and post-menopausal females (1.812 (1.717–1.907), p < 0.001). In euthyroid subjects, LnTSH and TyG index were significantly correlated in females. In conclusion, both hyperthyroidism and hypothyroidism might be associated with IR but by different mechanisms. It might be helpful to assess IR with appropriate indexes in patients with thyroid dysfunction.
Highlights
Insulin resistance (IR) is known as a risk factor for hyperglycemia, dyslipidemia, and hypertension, which contribute to the development of atherosclerosis
The aim of this study was to investigate the relationship between thyroid function and insulin resistance (IR) assessed by the triglyceride glucose (TyG) index and homeostasis model assessment of insulin resistance (HOMA-IR) with representative Korean population data
We investigated the relationship between thyroid function and IR using data from the Korean National Health and Nutrition Examination Survey (KNHANES) VI, and showed that overt hypothyroidism is correlated with increased IR represented by the TyG index in premenopausal females
Summary
Insulin resistance (IR) is known as a risk factor for hyperglycemia, dyslipidemia, and hypertension, which contribute to the development of atherosclerosis. The triglyceride glucose (TyG) index, calculated from triglycerides and fasting glucose, has been proposed as a reliable and simple surrogate marker of IR in many study fields. This index was not inferior to the HEC or the HOMA-IR for recognizing IR in several human s tudies[14,15,16]. The relationship between thyroid hormones and the TyG index has not been investigated widely. The aim of this study was to investigate the relationship between thyroid function and IR assessed by the TyG index and HOMA-IR with representative Korean population data
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