Association between thyroid function and metabolic syndrome in male and female schizophrenia patients

Abstract

BackgroundThe aim of this study was to analyse the relationship between thyroid function and the diagnosis of metabolic syndrome (MS) and its components in schizophrenia patients to improve the overall clinical care. MethodsWe examined 106 schizophrenia patients (64 females and 42 males, aged 18–69 years). Sociodemographic, psychometric, anthropometric, and biochemical measures; eating habits, and the use of selected drugs were assessed during the enrolment and after 8 to 10 weeks of observation. ResultsAn association between hyperglycaemia and hypothyroidism was observed. Compared to females, adverse metabolic profiles in male subjects were more common after follow-up, particularly in the presence of hypothyroidism. There was a significant reduction in hip circumference, blood glucose, and systolic blood pressure values after the follow-up period. ConclusionsBased on hypothyroidism incidence in the studied sample and the association between thyroid-stimulating hormone (TSH) values and MS criteria, we suggest regular assessment of TSH levels in schizophrenia patients with a diagnosis of MS. Programs of MS and thyroid dysfunction prevention and treatment in schizophrenia patients should be differentiated according to gender. An indirect conclusion is that even a minute element such as conducting the interview about lifestyle may trigger patients to change their habits.