Abstract
BackgroundThe ovarian function and therefore the ovarian reserve may be compromised by the pathogenesis of autoimmune diseases of which, Hashimoto’s thyroiditis (HT) is the most common in women of reproductive age. Furthermore, a prolonged reduction in thyroid hormone concentration results in a broad spectrum of reproductive alteration. Previous reports in the literature have been controversial regarding the impact of hypothyroidism and alterations in the ovarian reserve. Thus, this prospective and comparative study aimed to evaluate the association of hypothyroidism with low ovarian reserve.Materials and MethodsA subset of 27 patients with primary autoimmune hypothyroidism were compared to healthy women. The ovarian reserve was assessed through the anti-Mullerian hormone (AMH) and the antral follicle count (AFC).ResultsOverall, the two groups did not display significant differences in length of their menstrual cycles neither in the AMH serum levels nor the AFC.ConclusionsNo significant alteration was found in the ovarian reserve of women with HT.
Highlights
The ovarian function and the ovarian reserve may be compromised by the pathogenesis of autoimmune diseases of which, Hashimoto’s thyroiditis (HT) is the most common in women of reproductive age
No significant alteration was found in the ovarian reserve of women with HT
Some reports have claimed that low levels of thyroid hormones produce a significant decrease in basal luteinizing hormone (LH) release resulting in ovarian atrophy [14] or prolonged periods of vaginal diestrus [15, 16]
Summary
The ovarian function and the ovarian reserve may be compromised by the pathogenesis of autoimmune diseases of which, Hashimoto’s thyroiditis (HT) is the most common in women of reproductive age. Previous reports in the literature have been controversial regarding the impact of hypothyroidism and alterations in the ovarian reserve. This prospective and comparative study aimed to evaluate the association of hypothyroidism with low ovarian reserve. The most common autoimmune disease in women of reproductive age is the thyroid dysfunction with a prevalence of 5–20 % [5,6,7]. The DOR is defined by a reduced response to ovarian stimulation in women of reproductive age with regular menstrual cycles when compared to women of equivalent age
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