Abstract
The X-ray repair cross-complementing group 3 (XRCC3) is a highly suspected candidate gene for cancer susceptibility. Attention has been drawn upon associations of the XRCC3 Thr241Met polymorphism with breast cancer risk. However, the previous published findings remain controversial. Hence, we performed a meta-analysis to accurately evaluate any association between breast cancer and XRCC3 T241M (23, 812 cases and 25, 349 controls) in different inheritance models. PubMed and Web of Science databases were searched systematically until December 31, 2013 to obtain all the records evaluating the association between the XRCC3 Thr241Met polymorphism and breast cancer risk. Crude odds ratios (ORs) together with 95% confidence intervals (CIs) were used to assess the strength of associations. When all eligible studies were pooled into the meta analysis of XRCC3 T241M polymorphism, a significantly increased breast cancer risk was observed in heterozygote comparison (OR=1.06, 95%CI=1.01-1.12). No significant associations were found in other models. In subgroup analysis, this polymorphism seemed to be associated with elevated breast risk in Asians. No publication bias was detected. This meta-analysis suggests that the T241M polymorphism confers a weakly increased breast cancer risk. A study with the larger sample size is needed to further evaluate gene-gene and gene-environment interactions of the XRCC3 T241M polymorphism with breast cancer risk.
Highlights
Breast cancer is one of the most common cancers among females worldwide so far and is the leading cause of cancer-related mortality for almost 14% of all cancer deaths (Jemal et al, 2011)
Attention has been drawn upon associations of the X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism with breast cancer risk
Materials and Methods: PubMed and Web of Science databases were searched systematically until December 31, 2013 to obtain all the records evaluating the association between the XRCC3 Thr241Met polymorphism and breast cancer risk
Summary
Breast cancer is one of the most common cancers among females worldwide so far and is the leading cause of cancer-related mortality for almost 14% of all cancer deaths (Jemal et al, 2011) It is a heterogeneous disease caused by interactions of environmental and genetic factors. Chang-Fei Mao et al that XRCC3 T241M polymorphism is associated with among studies (Mantel and Haenszel, 1959);otherwise, the increased cancer risk when all studies were pooled random-effects model (the DerSimonian-Laird method) together. Given the essential role of XRCC3gene in bias among the control group was evaluated by the tumorigenesis, we conducted a meta-analysis to evaluate HWE using the chi-square test, and a p-value
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