Association between the VDR FokI Polymorphism, Muscle Strength and Bone Strength in Male and Female Adults

Abstract

PURPOSE The purpose of this study was to investigate the relationship between the VDR Fok I gene polymorphism and basic physical fitness including bone strength (calcaneus) in male and female adults. METHODS FokI VDR polymorphisms were genotyped in 191 men (36.7±12.3 years) and 218 women (33.5±12.1 years). Basic physical fitness (50 m run, handgrip strength, back strength, push-up, sit-up) and body weight were measured and analyzed using ANOVA. RESULTS No association was found between the VDR FokI genotypes and bone strength (calcaneus) including body mass in men and women. However, the handgrip strength (HGS) was 5.2-6.7% higher in women with the FF and Ff FokI genotype than in women with the ff genotype (p<.05, p<.05, respectively). CONCLUSIONS Female VDR FokI FF homozygotes and Ff heterozygotes showed higher HGS than ff homozygotes. On the other hand, there was no statistically significant difference in both handgrip and back strengths for male, but both VDR FokI FF and Ff genotypes showed higher tendency than ff genotype. Therefore, the VDR FokI gene polymorphism is considered to be a useful candidate gene especially reflecting female muscle strength. 색인어: VDR FokI ìœ ì „ìžë‹¤í˜•ì„±, ê·¼ë ¥, 골강도, ì• ë ¥ Keywords: VDR FokI polymorphism, Muscle strength, Bone strength, Handgrip